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Lentivirus (LV) Production

Pall's end-to-end process support, from development to industrialization with a set of scalable solutions for lentivirus production.

End-to-end process support, from development to industrialization

Lentiviral vectors are one of the most commonly used viral vectors for therapeutic purposes due to their specific functional properties, such as their ability to infect non-dividing cells and packaging capacity. The RNA-based vector has been designed to deliver genes to mammalian cells safely and effectively, and there are several therapies using lentiviral vectors currently under development and in human clinical trials.  Developing an efficient process for producing a lentiviral vector-based therapy is not easy. Purification of these 80-120 nm envelope vectors is challenging due to their low stability.   

 

There are multiple strategies for developing lentiviral vectors, but most follow the same basic process, with some variation as needed.   

 

 

Upstream

     

 

 

Downstream

     

 

Poster: Scaling-Up and Industrializing the Production of Viral Vectors and Cells for Therapeutic Use

 

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Poster:

Single-Use Platform for Scalable Purification of a VSV-G Lentiviral Vector

 

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Upstream

Adherent Cell Seeding

Adherent Cell Culture

Suspension Cell Seeding & Cell Culture

Clarification

Want to learn more about 

Upstream Process 

workflows? 

Speak to an expert

 

Downstream

Purification (Chromatography)

Ultrafiltration/Diafiltration (UF/DF)

Bulk Drug Substance Filtration

Want to learn more about 

Downstream Process 

workflows? 

Speak to an expert

 

Connect With An Expert

 

 

 

 

Pall has a global team of over 300 experienced technical professionals to support your molecule from pre-clinical to commercial manufacturing. From process development services and end-to-end platforms, to on-site testing and applications support for specific process steps, Pall will help you find the best solution based on data and testing.